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Leonello (1407-1450), who succeeded Niccolò, was cultivated classical writings, philosophy, and history while Borso (1413-1471) was more interested in law and medicine and provided great support for the university. Isabella, the daughter of Ercole I (1431-1505) born in 1471, inherited her father’s passion for the arts and, after her marriage to the Marquis of Mantua, became one of his chief competitors in collecting art.
Under Ercole I, Ferrara became one of the political powers and cultural centers of Europe. Composers came to Ferrara from many parts of Europe, especially France and Flanders; Josquin Des Prez, Jacob Obrecht, and Antoine Brumel all served during his reign. His son Alfonso I (1476-1534) was also an important patron; his preference for instrumental music resulted in Ferrara becoming an important center of composition for the lute. He also was a patron of the poets Pietro Bembo and Ludovico Ariosto. After his marriage to the notorious Lucrezia Borgia, Alfonso I was excommunicated by Pope Julius II, and attacked the pontifical army in 1512 outside Ravenna. He got on better with later popes, but relations between Ferrara and the Vatican remained strained throughout the sixteenth century.
Alfonso I’s son Ercole II (1508-1559) married Renée, daughter of Louis XII of France. He joined the pope and France against Spain in 1556, but made a separate peace in 1558. He also was a patron of the arts, as was his brother, Ippolito II, Cardinal d'Este (1509–72), an able diplomat who led the pro-French party at the papal court. Ippolito built the celebrated Villa d'Este at Tivoli. Ippolito was responsible for bringing Palestrina to the Este court during the 1560s. Another son of Ercole II, Alfonso II married Lucrezia, daughter of grand-duke Cosimo I of Tuscany, then Barbara, sister of the emperor Maximilian II and finally Margherita Gonzaga, daughter of the duke of Mantua. He raised the glory of Ferrara to its highest point, and was the patron of Torquato Tasso and Giovanni Battista Guarini.
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